Brief Report IMMUNOBIOLOGY New role for the (pro)renin receptor in T-cell development
نویسندگان
چکیده
Experimental and Clinical Research Center, an institutional cooperation between the Charité Medical Faculty and the Max-Delbruck Center for Molecular Medicine, Berlin, Germany; Max-Delbruck Center for Molecular Medicine, Berlin, Germany; Faculty of Medicine, Dresden University of Technology, Dresden, Germany; Department of Neurology, University of Erlangen, Erlangen, Germany; Stem Cells and Immune Regeneration Laboratory, Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia; HELIOS-Klinikum Berlin, Berlin, Germany; INSERM and College de France, Center for Interdisciplinary Research in Biology, Paris, France; Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany;
منابع مشابه
New role for the (pro)renin receptor in T-cell development.
The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T-cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease...
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The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor, angiotensin type 1 receptor blocker, and renin inhibitor therapies are mediated in part by their modification of the levels and actions of angiotensin peptides. Despite its long history, the RAS remains an active area of rese...
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تاریخ انتشار 2015